The definition of a metropolis is a large or main city. An example of a metropolis is Manhattan, New York. YourDictionary definition and usage example. A metropolis is a large city or conurbation which is a significant economic, political, and cultural center for a country or region, and an important hub for regional or international connections, commerce, and communications. The term is Greek (Greek: Μητρόπολη) and means the "mother city" of a Etymology and modern · Global city · Asia · Europe. A major city, especially the chief city of a country or region: Chicago, the metropolis of the Midwest. 2. A city or an urban area regarded as the center of a specific.